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Table 1 LPS induces GM-SCF, G-CSF, LIF, and IL-6 mRNAs in bone marrow stromal cells

From: Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study

Gene

N

Mean Fold Changea ± SE

P-valueb

IL-11

4

1.3 ± 0.2

0.27

IL-7

5

0.9 ± 0.2

0.58

GM-CSF

3

Increasedc

-

G-CSF

4

Increasedc

-

LIF

5

5.7 ± 1.2

0.02*

IL-6

7

7.0 ± 1.5

0.01*

SCF

4

1.1 ± 0.1

0.40

M-CSF

5

1.0 ± 0.1

0.79

TGF-β1

2

1.2, 1.4

0.26

TGF-β3

2

0.8, 0.9

0.18

MIF

2

0.9, 1.0

0.52

  1. a From the Ribonuclease Protection Assays (RPAs), mean fold-change was determined by normalizing the optical density band of the LPS-treated sample to the housekeeping gene GAPDH or L-32, then expressing it relative to the optical density of the normalized band from the vehicle-treated sample. b Based on one-sample t-test to determine whether mean was significantly different from maximum LPS induction (μ = 1.0). c Expression of GM-CSF and G-CSF was sometimes undetectable in unstimulated cells, thus the LPS-induced expression could not be described appropriately as "fold change" * p < 0.05