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Table 4 Joint associations between exposure to ambient volatile organic compounds, ethnic enclaves, and gestational diabetes mellitus among Asian/Pacific Islander women in the Consortium on Safe Labor (2002–2008)

From: Joint effects of ethnic enclave residence and ambient volatile organic compounds exposure on risk of gestational diabetes mellitus among Asian/Pacific Islander women in the United States

 

Preconception

First Trimester

VOC

(High = ≥ 75th percentile)

Enclave

n

(N = 9069)

Odds Ratio

(95% CI)

n

(N = 9069)

Odds Ratio

(95% CI)

Benzene

Low

Yes

242

Ref.

245

Ref.

No

4115

2.85 (1.57, 5.17)a

4179

2.38 (1.36, 4.16)a

High

Yes

1649

2.07 (1.09, 3.94)a

1646

1.65 (0.90, 3.03)

No

3063

3.45 (1.77, 6.72)a

2999

2.70 (1.45, 5.03)a

Ethylbenzene

Low

Yes

245

Ref.

245

Ref.

No

3916

2.43 (1.37, 4.32)a

3943

2.30 (1.29, 4.09)a

High

Yes

1646

1.70 (0.90, 3.22)

1646

1.56 (0.82, 2.95)

No

3262

2.76 (1.32, 5.75)a

3235

2.29 (1.10, 4.77)a

MTB Ether

Low

Yes

738

Ref.

596

Ref.

No

4578

1.38 (1.02, 1.87)a

4436

1.40 (1.01, 1.95)

High

Yes

1153

0.87 (0.58, 1.31)

1295

0.90 (0.60, 1.36)

No

2600

1.84 (1.34, 2.52)a

2742

1.88 (1.33, 2.66)a

N-hexane

Low

Yes

535

Ref.

410

Ref.

No

3834

1.56 (1.11, 2.20)a

3984

1.72 (1.16, 2.55)a

High

Yes

1356

1.03 (0.68, 1.57)

1481

1.16 (0.74, 1.83)

No

3344

2.09 (1.39, 3.15)a

3194

2.25 (1.43, 3.53)a

EMK

Low

Yes

739

Ref.

627

Ref.

No

4827

1.62 (1.19, 2.20)a

4615

1.43 (1.04, 1.96)a

High

Yes

1152

1.09 (0.72, 1.63)

1264

0.85 (0.57, 1.28)

No

2351

1.84 (1.32, 2.58)a

2563

1.67 (1.18, 2.36)a

m-xylene

Low

Yes

245

Ref.

245

Ref.

No

3909

2.33 (1.31, 4.15)a

3926

2.30 (1.29, 4.08)a

High

Yes

1646

1.59 (0.84, 3.01)

1646

1.55 (0.82, 2.94)

No

3269

2.40 (1.15, 5.00)a

3252

2.27 (1.08, 4.76)a

o-xylene

Low

Yes

304

Ref.

246

Ref.

No

3897

2.37 (1.42, 3.98)a

3936

2.35 (1.32, 4.17)a

High

Yes

1587

1.66 (0.94, 2.94)

1645

1.60 (0.85, 3.04)

No

3281

2.52 (1.30, 4.87)a

3242

2.42 (1.15, 5.09)a

p-xylene

Low

Yes

438

Ref.

338

Ref.

No

3868

1.87 (1.25, 2.78)a

3900

1.93 (1.23, 3.03)a

High

Yes

1453

1.27 (0.80, 2.03)

1553

1.29 (0.77, 2.16)

No

3310

2.02 (1.20, 3.40)a

3278

1.93 (1.06, 3.53)a

Propene

Low

Yes

827

Ref.

945

Ref.

No

4728

1.44 (1.07, 1.93)a

4471

1.45 (1.09, 1.93)a

High

Yes

1064

0.93 (0.64, 1.36)

946

0.94 (0.66, 1.34)

No

2450

1.99 (1.46, 2.72)a

2707

1.96 (1.44, 2.67)a

Sesquiterpene

Low

Yes

818

Ref.

741

Ref.

No

3753

1.55 (1.15, 2.10)a

3841

1.38 (1.02, 1.87)a

High

Yes

1073

1.13 (0.77, 1.65)

1150

0.87 (0.59, 1.28)

No

3425

2.23 (1.59, 3.14)a

3337

1.91 (1.36, 2.69)a

Toluene

Low

Yes

334

Ref.

245

Ref.

No

3891

2.39 (1.45, 3.95)a

3934

2.31 (1.30, 4.11)a

High

Yes

1557

1.68 (0.96, 2.91)

1646

1.57 (0.83, 2.97)

No

3287

2.38 (1.25, 4.52)a

3244

2.31 (1.09, 4.89)a

Styrene

Low

Yes

736

Ref.

619

Ref.

No

6268

1.41 (1.04, 1.93)a

6266

1.47 (1.05, 2.06)a

High

Yes

1155

0.84 (0.56, 1.26)

1272

0.89 (0.59, 1.34)

No

910

1.59 (1.13, 2.24)a

912

1.56 (1.08, 2.25)a

1,3 butadiene

Low

Yes

732

Ref.

595

Ref.

No

6197

1.39 (1.02, 1.88)a

6354

1.48 (1.06, 2.06)a

High

Yes

1159

0.83 (0.55, 1.25)

1296

0.86 (0.57, 1.29)

No

981

1.67 (1.19, 2.33)a

824

1.46 (1.01, 2.13)a

Cyclohexane

Low

Yes

1022

Ref.

1016

Ref.

No

3747

1.86 (1.37, 2.53)a

3794

1.70 (1.26, 2.28)a

High

Yes

869

1.31 (0.92, 1.87)

875

1.08 (0.76, 1.54)

No

3431

1.73 (1.15, 2.59)a

3384

1.46 (0.98, 2.18)

  1. Analytic sample restricted to Asian/Pacific Islander women without diagnosed preconception diabetes. Hierarchical logistic regression, women nested within hospital referral region. Models adjusted for maternal age, preconception BMI, parity, insurance status, hospital, marital status, area-level poverty, season of birth. astatistically significant after Benjamini-Hochberg procedure (false discovery rate = 10%)