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Table 5 Scientific considerations

From: Advancing the science on chemical classes

Physical-chemical properties

Toxicity Profile

Occurrence

• Persistent

• Bioaccumulative

• Mobile

• Structurally similar

• Shared precursors, metabolic pathways, breakdown products

• Carcinogenicity

• Reproductive toxicity

• Developmental toxicity

• Neurotoxicity

• Immunotoxicity

• Other organ or system toxicities (hepatic, respiratory, renal, cardiovascular)

• Endocrine disruption

• Similar effects in: organs, systems, molecular pathways

• Shared key characteristics, adverse outcome pathways or networks

• Functionality (uses)

• Generated by same processes

• Co-exposure

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Environmental Health

ISSN: 1476-069X