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Table 4 Respiratory microbiology, fungal disease and mean ppFEV1 among children and adults with CF within and beyond 4 km of PCS in the UK in 2016. p-value < 0.05 are shown in bold

From: Assessing the health risk of living near composting facilities on lung health, fungal and bacterial disease in cystic fibrosis: a UK CF Registry study

 

Distance band

Distance band

Crude

Adjusted*

 ≤ 4 km

 > 4 km

p-value

 ≤ 4 km

 > 4 km

p-value

Total Number of pwCF (n)

866

6,934

-

-

-

-

Number of pwCF who had culture** (n)

842

6,730

-

-

-

-

A. fumigatus

n (point prevalence %)

129 (15.3)

1,041 (15.5)

0.911

   

mean ppFEV1

  Children

77.2

79.0

0.662

78.3

80.4

0.631

  Adults

55.9

62.1

0.001

58.2

62.0

0.005

ABPA

n (point prevalence %)

76 (8.8)

551 (7.9)

0.397

   

mean ppFEV1

  Children

81.2

75.3

0.229

86.6

82.6

0.179

  Adults

60.2

59.1

0.717

60.3

60.1

0.696

Candida spp.

n (point prevalence %)

180 (21.4)

1,195 (17.8)

0.010

   

mean ppFEV1

  Children

79.6

79.3

0.929

84.0

82.9

0.921

  Adults

53.6

57.8

0.048

56.9

59.9

0.029

P. aeruginosa

n (point prevalence %)

439 (52.1)

3,377 (50.2)

0.284

   

mean ppFEV1

  Children

80.5

82.3

0.436

80.9

84.1

0.399

  Adults

56.8

58.1

0.280

58.5

59.6

0.240

S. aureus

n (point prevalence %)

76 (8.3)

558 (9.0)

0.469

   

mean ppFEV1

  Children

71.2

76.1

0.541

63.7

70.8

0.472

  Adults

58.0

56.9

0.690

59.1

59.0

0.663

  1. Aspergillus fumigatus = A. fumigatus, Pseudomonas aeruginosa = P. aeruginosa, Staphylococcus aureus = S. aureus
  2. *Adjusted for age, sex, BMI (children model adjusted for BMI percentile and adult model adjusted for absolute BMI), genotype and deprivation
  3. **(Sputum/ Cough Swab/ Bronchoscopy); ppFEV1 percent predicted with FEV1, pwCF people with cystic fibrosis, ABPA Allergic Bronchopulmonary Aspergillosis, PCS permitted composting site; Children = 6—15 years; adult = 16—86 years