Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)

Ehrlich, Veronika; Bil, Wieneke; Vandebriel, Rob; Granum, Berit; Luijten, Mirjam; Lindeman, Birgitte; Grandjean, Philippe; Kaiser, Andreas-Marius; Hauzenberger, Ingrid; Hartmann, Christina; Gundacker, Claudia; Uhl, Maria

doi:10.1186/s12940-022-00958-5

Environmental Health

Table 1 Literature research: databases, search terms and search combinations (see Methods section). Within the frame of this review, this database was used for experimental studies (in vitro and in vivo)

From: Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)

Database	Date	Keyword A	Keyword B	N
Web of Sciences	08.06.2021	PFAS	immune, TDAR, TIAR, TIAR, SRBC, IgG, IgE, Host infection studies, viral infection, bacterial infection, innate immunity, hypersensitivity, B-cell function, plasma cell function, lymphotoxicity, Lym, thymus atrophy, thymu, spleen atrophy, spleen, thymus cellularity, spleen cellularity, PPAR*	88
Web of Sciences	09.06.2021	PFAS	natural killer cell, cytokine, IL-1R1, IL-1Ra, interleukin, NF-kB, macrophage, mast cells, histamine, hexosaminidase, IFN-gamma, T-cell, reactive oxygen species, mitochondria, apoptosis, host infection, inflammasome, Nrf-2, Nrf2, NFAT, calci, neopterin, tryptophan, glucocorticoid, JAK3, p53, Bax, superoxiddismutase, superoxid, glutathion, GST, lipid peroxidation, caspase, BcL-2, BcL2, fatty acid metabolism, innate immunity, hypersensitivity, asthma, allerg*, respiratory infection, autoimmunity	185
Web of Sciences	23.06.2021	perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	TDAR, TIAR, SRBC, KLH, HRBC, “host infection”, T-cell, infect,	3
PubMed	10.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	immune, TDAR, T-cell, TIAR, SRBC, IgG, IgE, “host infection”, “viral infection”, “bacterial infection”, “innate immunity”, hypersensitivity	192
PubMed	11.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	B-cell, “plasma cell function”, lymphotoxicity, “thymus atrophy”, “spleen atrophy”, “thymus cellularity”, “spleen cellularity”, PPAR, “natural killer”, cytokines	192
PubMed	12.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	cytokines, interleukin, NF-kB, macrophage, “mast cells”, histamine, hexosaminidase, IFN-gamma,	108
PubMed	13.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	“reactive oxygen species”, mitochondria, apoptosis, inflammasome, Nrf-2, Nrf2, NFAT, calcium, neopterin, tryptophan, “glucocorticoid receptor”, JAK3, p53, Bax, “superoxid dismutase”, glutathione, “GSH-transferase”, GST,	187
PubMed	14.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	Inflammasome, Nrf-2, Nrf2, NFAT, calcium, neopterin, tryptophan, “glucocorticoid receptor”, JAK3, p53, Bax, “superoxid dismutase”, “glutathione”, “GSH-transferase”, GST,	191
PubMed	15.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	“lipid peroxidation”, caspase	41
PubMed	17.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	BcL-2, BcL2, “fatty acid metabolism”, “innate immunity”, hypersensitivity, asthma	116
PubMed	18.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	asthma, allergies, “respiratory infection”, autoimmunity,	160
PubMed	20.06.2021	PFAS, perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	infection	141
Scopus	08/09.07.2021	perfluor, polyfluor, PFBS, PFHxS, PFOS, PFBA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, HFPO-DA, GenX	immune, TDAR, TIAR, SRBC, KLH, HRBC, PPAR, infect, T-cell, antibod	80

Please see also List of Abbreviations, for description of Table see Methods section

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