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Table 3 SEM results of mediation analysis for TL

From: The effect of high polycyclic aromatic hydrocarbon exposure on biological aging indicators

 

Endogenous variables

Exogenous variables

Beta Coef.

95%CI

p-value

Lower

Upper

Structural Equations

TL

Occup_PAHs

−0.002

−0.003

−0.001

0.000

Environ_PAHs

−3.783

−7.928

0.363

0.074

nDNA_changes

0.008

−0.04

0.04

0.966

nDNA_changes

Occup_PAHs

0.021

0.002

0.040

0.040

Environ_PAHs

19.69

12.16

27.23

0.000

Measurement

Diet ← Environ_PAHs

1

(constrained)

 

Indoor ← Environ_PAHs

7.608

5.466

9.750

0.000

Outdoor ← Environ_PAHs

11.78

7.098

16.47

0.000

Home ← Environ_PAHs

12.09

−1.024

25.20

0.071

MN← nDNA_changes

1

(constrained)

 

Anti-BPDE-DNA adducts ← nDNA_changes

1.829

1.429

2.229

0.000

LINE-1 (%mC) ←nDNA_changes

1.417

1.405

1.429

0.000

p53 (%mC) ← nDNA_changes

−2.519

−2.624

−2.414

0.000

Alu (%mC) ← nDNA_changes

0.235

0.208

0.261

0.000

HICI (%mC) ← nDNA_changes

−0.915

−1.133

−0.697

0.000

IL-6 (%mC) ← nDNA_changes

1.572

0.824

2.320

0.000

p16 (%mC) ← nDNA_changes

-0.052

-0.057

-0.048

0.000

GSTM1 ← nDNA_changes

0.016

-0.031

0.063

0.504

Covariances

cov(Occup_PAHs,Environ_PAHs)

0.122

-0.463

0.706

0.683

  1. Three groups of (structural equations, measurement and covariances) for the mediation analysis; standardized beta coefficients (with “minus” sign indicating inverse relationship) with lower and upper limit of 95% confidence intervals (95%CI) and p-values. Standard Error adjusted for 2 clusters (coke-oven workers and controls). Number of observations = 87
  2. Abbreviations: TL Telomere length, Chronic_d Chronic diseases, nDNA_changes Latent variable estimated by SEM (overall change of DNA) based on MN, Anti-BPDE-DNA adducts, LINE-1, p53, Alu, HICI, IL-6, p16, GSTM1, Environ_PAHs Latent variable estimated by SEM (environmental exposure to PAHs) based on diet, features ofhome, indoor and outdoor activities, MN Micronuclei, PAHs Exposure to Polycyclic aromatic hydrocarbons, Occup_PAHs (years of work in the cokery) × (1-pyrenol in μmoles/mol creatinine)
  3. Goodness of fit statistics: Standardized root mean squared residual (SRMR) = 0.092; Coefficient of determination (CD) = 0.914; Stability index = 0 (SEM satisfies stability condition)
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Environmental Health

ISSN: 1476-069X