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Table 4 Associations between exposure to air pollution and flow-mediated dilation (%) after stratification by age and sexa, b

From: Age and sex differences in the effects of short- and long-term exposure to air pollution on endothelial dysfunction

 

Stratified by

7-day

14-day

12-month

β (95% CI)

P value

β (95% CI)

P value

β (95% CI)

P value

PM2.5, per 10 µg/m3

P for interaction

 

0.144

 

0.482

 

0.140

 

< 65 years

-0.10 (-0.18, -0.01)

0.028

-0.04 (-0.14, 0.07)

0.476

-0.28 (-0.47, -0.08)

0.006

 

≥ 65 years

-0.02 (-0.12, 0.07)

0.653

-0.01 (-0.15, 0.12)

0.855

0.03 (-0.21, 0.28)

0.800

 

P for interaction

 

0.186

 

0.294

 

0.101

 

Male

-0.09 (-0.16, -0.01)

0.021

-0.05 (-0.15, 0.04)

0.285

-0.27 (-0.45, -0.09)

0.004

 

Female

-0.03 (-0.17, 0.11)

0.651

-0.01 (-0.18, 0.15)

0.868

-0.03 (-0.32, 0.26)

0.858

PM10, per 10 µg/m3

P for interaction

 

0.138

 

0.418

 

0.184

 

< 65 years

-0.08 (-0.14, -0.01)

0.018

-0.05 (-0.13, 0.03)

0.240

-0.32 (-0.54, -0.10)

0.004

 

≥ 65 years

-0.009 (-0.09, 0.07)

0.824

-0.007 (-0.11, 0.10)

0.894

-0.02 (-0.29, 0.24)

0.861

 

P for interaction

 

0.274

 

0.330

 

0.205

 

Male

-0.07 (-0.13, -0.01)

0.016

-0.06 (-0.14, 0.01)

0.111

-0.31 (-0.51, -0.11)

0.003

 

Female

-0.02 (-0.12, 0.08)

0.655

-0.003 (-0.13, 0.12)

0.965

-0.10 (-0.42, 0.22)

0.526

SO2, per 1 µg/m3

P for interaction

 

0.115

 

0.190

 

0.148

 

< 65 years

-0.05 (-0.12, 0.02)

0.126

-0.04 (-0.13, 0.04)

0.290

-0.18 (-0.30, -0.06)

0.003

 

≥ 65 years

0.04 (-0.06, 0.15)

0.415

0.02 (-0.08, 0.13)

0.658

0.011 (-0.14, 0.16)

0.886

 

P for interaction

 

0.036

 

0.078

 

0.055

 

Male

-0.07 (-0.13, -0.005)

0.034

-0.06 (-0.13, 0.01)

0.099

-0.19 (-0.30, -0.08)

< 0.001

 

Female

0.07 (-0.05, 0.20)

0.252

0.08 (-0.07, 0.23)

0.275

-0.02 (-0.19, 0.16)

0.862

NO2, per 10 µg/m3

P for interaction

 

0.194

 

0.157

 

0.161

 

< 65 years

-0.08 (-0.29, 0.14)

0.482

-0.003 (-0.26, 0.26)

0.984

-0.88 (-1.40, -0.36)

< 0.001

 

≥ 65 years

-0.01 (-0.25, 0.22)

0.909

0.06 (-0.25, 0.37)

0.703

-0.16 (-0.78, 0.47)

0.620

 

P for interaction

 

0.072

 

0.272

 

0.174

 

Male

-0.11 (-0.30, 0.08)

0.251

0.002 (-0.24, 0.24)

0.985

-0.84 (-1.31, -0.37)

< 0.001

 

Female

0.07 (-0.25, 0.39)

0.684

0.004 (-0.37, 0.38)

0.985

-0.33 (-1.10, 0.45)

0.412

CO, per 0.1 mg/m3

P for interaction

 

0.463

 

0.779

 

0.151

 

< 65 years

-0.03 (-0.09, 0.03)

0.267

0.02 (-0.05, 0.09)

0.521

-0.17 (-0.28, -0.05)

0.005

 

≥ 65 years

-0.02 (-0.08, 0.04)

0.549

-0.04 (-0.13, 0.05)

0.423

0.01 (-0.13, 0.16)

0.858

 

P for interaction

 

0.081

 

0.074

 

0.091

 

Male

-0.04 (-0.09, 0.006)

0.088

-0.02 (-0.08, 0.04)

0.537

-0.17 (-0.28, -0.06)

0.003

 

Female

0.02 (-0.09, 0.14)

0.680

0.05 (-0.06, 0.16)

0.355

-0.02 (-0.19, 0.15)

0.836

O3, per 10 µg/m3

P for interaction

 

0.151

 

0.178

 

0.866

 

< 65 years

-0.09 (-0.18, 0.005)

0.063

-0.10 (-0.21, 0.008)

0.069

-0.75 (-1.77, 0.28)

0.153

 

≥ 65 years

-0.06 (-0.17, 0.05)

0.269

-0.04 (-0.17, 0.09))

0.555

-0.70 (-1.91, 0.50)

0.249

 

P for interaction

 

0.331

 

0.231

 

0.065

 

Male

-0.09 (-0.18, 0.001)

0.052

-0.08 (-0.18, 0.03)

0.144

-1.28 (-2.21, -0.35)

0.007

 

Female

-0.05 (-0.18, 0.08)

0.460

-0.08 (-0.23, 0.08))

0.326

0.21 (-1.25, 1.67)

0.776

  1. a PM2.5, fine particulate matter with aerodynamic diameter < 2.5 μm; PM10, inhalable particulate matter with aerodynamic diameter < 10 μm; SO2, sulfur dioxide; NO2, nitrogen dioxide; CO, carbon monoxide; O3, ozone; 95% CI, 95% confidence interval
  2. b Model adjusted for age group (< 65 years and ≥ 65 years), sex, body mass index, smoking status, temperature, season (warm: April to September; cold: October to March), cardiovascular disease, hypertension, diabetes mellitus, resting heart rate, and low-density lipoprotein cholesterol. The long-term exposure model did not adjust for temperature and season