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Table 1 Basic characteristics of study population by tertiles of titanium concentration

From: Titanium exposure and gestational diabetes mellitus: associations and potential mediation by perturbation of amino acids in early pregnancy

Basic characteristics

All participants

Tertiles of SG-corrected titanium (μg/L)

P

T1 (≤ 112.35)

T2 (112.35–184.41)

T3 (≥ 184.41)

Participants, n

1449

483

483

483

 

Study center

 Nanjing

1032 (71.2)

355 (73.5)

338 (70.0)

339 (70.2)

0.399

 Suzhou

417 (28.8)

128 (26.5)

145 (30.0)

144 (29.8)

 

Maternal age at recruitment, years

29.57 ± 3.74

29.49 ± 3.74

29.62 ± 3.79

29.61 ± 3.68

0.827

Pre-pregnancy BMI, kg/m2

21.21 (2.87)

21.13 (2.72)

21.45 (3.19)

21.05 (2.65)

0.068

  < 18.5

214 (14.8)

71 (14.7)

75 (15.5)

68 (14.1)

0.042

 18.5–23.9

1014 (70.0)

353 (73.1)

319 (66.0)

342 (70.8)

 

 24.0–27.9

176 (12.1)

47 (9.7)

66 (13.7)

63 (13.0)

 

  ≥ 28

44 (3.0)

12 (2.5)

23 (4.8)

9 (1.9)

 

 Missing

1 (0.1)

0 (0.0)

0 (0.0)

1 (0.2)

 

Residence area

 Urban/sub-urban

1087 (75.0)

346 (71.6)

372 (77.0)

369 (76.4)

0.107

 Rural

362 (25.0)

137 (28.4)

111 (23.0)

114 (23.6)

 

Household income, CNY

  < 100000

416 (28.7)

149 (30.8)

138 (28.6)

129 (26.7)

0.457

 100000–200000

679 (46.9)

216 (44.7)

221 (45.8)

242 (50.1)

 

  > 200000

353 (24.4)

118 (24.4)

123 (25.5)

112 (23.2)

 

 Missing

1 (0.1)

0 (0.0)

1 (0.2)

0 (0.0)

 

Maternal education, years

  < 12

131 (9.0)

45 (9.3)

38 (7.9)

48 (9.9)

0.515

  ≥ 12

1318 (91.0)

438 (90.7)

445 (92.1)

435 (90.1)

 

Parity

 0

1135 (78.3)

383 (79.3)

365 (75.6)

387 (80.1)

0.211

  ≥ 1

313 (21.6)

100 (20.7)

117 (24.2)

96 (19.9)

 

 Missing

1 (0.1)

0 (0.0)

1 (0.2)

0 (0.0)

 

Smoking during pregnancy

12 (0.8)

5 (1.0)

3 (0.6)

4 (0.8)

0.777

Drinking during pregnancy

26 (1.8)

6 (1.2)

5 (1.0)

15 (3.1)

0.028

Hypertensive disorders in pregnancya

48 (3.3)

22 (4.6)

15 (3.1)

11 (2.3)

0.135

75 g oral glucose tolerance test (n = 1360)

 OGTT screening gestational weeks

25.22 ± 0.95

25.24 ± 0.89

25.24 ± 0.93

25.18 ± 1.02

0.633

 FBG, mmol/l

4.40 ± 0.43

4.39 ± 0.41

4.38 ± 0.42

4.44 ± 0.46

0.121

 1-h PG, mmol/l

7.59 ± 1.62

7.40 ± 1.57

7.68 ± 1.64

7.71 ± 1.62

0.007

 1-h PG, mmol/l

6.62 ± 1.36

6.50 ± 1.34

6.66 ± 1.31

6.70 ± 1.42

0.070

  1. GDM gestational diabetes mellitus, BMI body mass index, SD standard deviation, CNY Chinese Yuan, OGTT oral glucose tolerance test, FBG fasting blood glucose; 1-h PG, oral glucose tolerance test 1-h plasma glucose; 2-h PG, oral glucose tolerance test 2-h plasma glucose. Data presented as mean ± SD or n (%)
  2. aHypertensive disorders in pregnancy includes chronic, gestational hypertension and pre-eclampsia