Association of polychlorinated biphenyls with vitamin D among rural Chinese adults with normal glycaemia and type 2 diabetes mellitus

Table 3 Estimated effect of PCBs, HOMA index and their interaction on vitamin D

Outcome	ΣPCBs (β,95%CI)	HOMA index (β,95%CI)	P_{ΣPCBs×HOMA index}
25(OH)D2
ΣPCBs	0.017 (-0.003, 0.036)	-	-
HOMA2-%β	-	0.099 (0.072, 0.126) *	-
HOMA2-IR	-	-0.105 (-0.146, -0.064) *	-
ΣPCBs + HOMA2-%β + ΣPCBs×HOMA2-%β	-0.187 (-0.317, -0.056) *	0.117 (0.087, 0.146) *	0.002
ΣPCBs + HOMA2-IR + ΣPCBs×HOMA2-IR	0.001 (-0.034, 0.036)	-0.097 (-0.140, -0.054) *	0.400
25(OH)D3
ΣPCBs	-0.026 (-0.044, -0.009) *	-	-
HOMA2-%β	-	-0.011 (-0.035, 0.013)	-
HOMA2-IR	-	-0.003 (-0.039, 0.034)	-
ΣPCBs + HOMA2-%β + ΣPCBs×HOMA2-%β	-0.139 (-0.254, -0.024) *	-0.001 (-0.027, 0.024)	0.056
ΣPCBs + HOMA2-IR + ΣPCBs×HOMA2-IR	-0.012 (-0.043, 0.018)	-0.015 (-0.053, 0.022)	0.204
25(OH)D
ΣPCBs	-0.018 (-0.033, -0.002) *	-	-
HOMA2-%β	-	0.016 (-0.005, 0.037)	-
HOMA2-IR	-	-0.030 (-0.062, 0.002)	-
ΣPCBs + HOMA2-%β + ΣPCBs×HOMA2-%β	-0.157 (-0.258, -0.055) *	0.028 (0.006, 0.051) *	0.007
ΣPCBs + HOMA2-IR + ΣPCBs×HOMA2-IR	-0.010 (-0.037, 0.017)	-0.038 (-0.072, -0.005) *	0.386

Abbreviations: PCBs, Polychlorinated biphenyls; HOMA: Homeostatic Model Assessment; HOMA2-IR: homeostasis model assessment 2 of insulin resistance; HOMA2-%β, β-cell function; ΣPCBs was summed by the seven PCBs measured above
Adjusted for age, gender, smoking status, alcohol consumption status, marriage status, educational levels, average monthly individual income, physical activity, BMI, and total lipids

ISSN: 1476-069X