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Table 2 Association of 5mdC (%), total urinary arsenic and blood lead and cadmium levels with developmental delay in preschool children

From: Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children

Variable

Children with developmental delay (n = 174)

Children without developmental delay (n = 88)

Age-sex-adjusted ORs (95% CI)

Multivariate ORs (95% CI)b

5mdC (%)

3.68 (3.19, 4.24) #,***

5.03 (3.91, 5.70) #,***

  

£ 4.28

131 (75.29

30 (34.09)

1.00 §,***

1.00 §,***

>4.28 – 5.45

21 (12.07)

28 (31.82)

0.13 (0.06 – 0.28) ***

0.09 (0.04–0.25) ***

> 5.45

22 (12.64)

30 (34.09)

0.15 (0.07 – 0.31) ***

0.14 (0.06–0.32) ***

Total urinary arsenic(μg/L)

15.98 (8.00, 28.05) #,+

12.55 (5.38, 23.41)#,+

  

≤ 7.06

36 (20.69)

30 (34.09)

1.00§,a,+

1.00 §,c,*

>7.06 – 18.46

65 (37.36)

29 (32.95)

1.71 (0.84 – 3.46)

1.79 (0.78 – 4.09)

> 18.46

73 (41.95)

29 (32.95)

2.21 (0.94 – 3.17)+

2.44 (0.89 – 6.70)+

Blood lead(μg/dL)

5.89 (3.59, 8.46) #,***

3.00 (2.37, 4.34) #,***

  

≤ 2.68

21 (12.64)

31 (35.23)

1.00§,***

1.00 §,***

>2.68 – 3.91

30 (17.24)

28 (31.82)

1.69 (0.76 – 3.75)

1.13 (0.44 – 2.89)

>3.91

122 (70.11)

29 (32.95)

6.35 (3.08 – 13.09)***

4.46 (1.92 – 10.39)***

Blood cadmium(μg/L)

0.90 (0.70, 1.35) #

0.85 (0.60, 1.35) #

  

≤ 0.70

45 (25.86)

30 (34.10)

1.00§,+

1.00

>0.70 – 1.15

68 (39.08)

29 (32.95)

1.67 (0.85 – 3.26)

1.75 (0.80 – 3.86)

>1.15

61 (35.06)

29 (32.95)

1.92 (0.96 – 3.85)+

1.38 (0.61 – 3.14)

  1. Note: Values are expressed as the median (first and third quartile) or the number of cases (%)
  2. Abbreviations: OR = odds ratio, CI = confidence interval. 5mdC (%) = ratio of 5-methyl-2'deoxycytidine
  3. aAdjusted for age, sex, and urinary creatinine
  4. bAdjusted for age, sex, birth weight, maternal education level, and number of gestational weeks
  5. cAdjusted for age, sex, birth weight, maternal education level, number of gestational weeks, and urinary creatinine
  6. #Calculated using the Wilcoxon rank-sum test
  7. +0.05 ≤ p < 0.1, *p < 0.05, ***p < 0.001
  8. §for trend tests