Environmental Health

Table 4 Associations between measures of serum-cholesterol and PFAS exposure (adjusted for age and BMI). n = 72

From: Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS

	Total cholesterol		LDL-C		HDL-C
PFAS	β^a	p-value^b	β	p-value	β	p-value
PFBA	0.015	0.731	0.017	0.755	-0.059	0.395
PFHxA	0.031	0.15	0.015	0.582	0.073	0.035
PFHpA	0.002	0.879	-0.006	0.712	0.053	0.009
PFOA	-0.007	0.848	-0.004	0.935	-0.026	0.674
PFNA	0.019	0.342	0.018	0.483	0.031	0.345
PFDA	-0.006	0.726	-0.005	0.823	-0.021	0.452
PFUdA	0.006	0.668	0.017	0.302	-0.031	0.157
PFHxS	-0.014	0.53	-0.025	0.35	0.036	0.301
PFOS	-0.006	0.847	0.017	0.67	-0.061	0.237
GenX	-0.003	0.779	0.003	0.796	-0.018	0.208
PFOSA	0.011	0.744	0.004	0.916	0.034	0.536
Total PFAS	-0.005	0.892	-0.002	0.971	-0.001	0.993
NASEM PFASs^c	-0.004	0.924	0.021	0.686	-0.052	0.444

^aβ = change in mmol of cholesterol biomarker per ln-ng PFAS increase in serum
^bMultivariable linear regression
NASEM PFASs include PFOA, PFNA, PFDA, PFUnDA, PFHxS, PFOS. Me-FOSAA concentrations were below the LOD

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