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Table 5 Effect of fiber beverage intervention on serum-PFAS concentrations

From: Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS

 

OBG (n=42)

Rice (n=30)

 

Baseline

4 weeks

GM Ratioa

p-valueb

Baseline

4 weeks

GM Ratioa

p-valueb

PFAS

GM (GSD)

GM (GSD)

B/W4

 

GM (GSD)

GM (GSD)

B/W4

 

PFBA

0.80 (1.6)

0.66 (1.6)

1.2

<0.01

0.73 (1.5)

0.58 (1.6)

1.3

0.01

PFHxA

0.59 (2.4)

0.51 (2.2)

1.2

0.06

0.58 (2.2)

0.45 (1.9)

1.3

0.02

PFHpA

0.37 (4.5)

0.30 (4.4)

1.2

<0.01

0.56 (3.4)

0.38 (2.9)

1.5

0.01

PFOA

1.74 (1.7)

1.61 (1.8)

1.1

0.14

1.87 (1.6)

1.85 (1.8)

1

0.8

PFNA

0.70 (3.1)

0.66 (3.1)

1.1

0.14

1.07 (1.7)

1.07 (1.7)

1

0.98

PFDA

0.10 (3.2)

0.10 (3.2)

1

0.84

0.13 (2.5)

0.14 (2.5)

0.9

0.4

PFUdA

0.13 (4.4)

0.13 (4.3)

1

0.8

0.20 (3.7)

0.20 (3.7)

1

0.89

PFHxS

1.09 (2.6)

1.00 (2.5)

1.1

0.07

1.56 (2.2)

1.53 (1.8)

1

0.88

PFOS

3.91 (1.8)

3.59 (2.0)

1.1

0.12

4.50 (2.0)

4.31 (2.1)

1

0.35

GenX

0.29 (6.4)

0.28 (6.7)

1

0.77

0.83 (11.0)

0.66 (8.1)

1.3

0.29

PFOSA

6.91 (1.8)

6.55 (1.8)

1.1

0.5

7.27 (1.8)

7.35 (1.8)

1

0.78

Total PFAS

19.2 (1.5)

17.7 (1.6)

1.1

0.08

24.9 (1.9)

21.6 (1.6)

1.2

0.05

NASEM PFASsd

8.6 (1.6)

7.9 (1.7)

1.1

0.03

10.1 (1.6)

9.7 (1.7)

1

0.27

  1. aGM ratios were calculated as the difference in ln-serum concentrations at baseline (B) and week 4 (W4) of the intervention of the paired data for each specific PFAS, NASEM PFASs and total sum
  2. bGM concentrations are reported in ng/ml
  3. cPaired t-tests were performed on ln-transformed data to compare PFAS concentrations at baseline vs. week 4
  4. dNASEM PFASs include PFOA, PFNA, PFDA, PFUnDA, PFHxS, PFOS. Me-FOSAA concentrations were below the LOD in all samples
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Environmental Health

ISSN: 1476-069X