Associations between dietary exposure to profiles of metalloestrogens and estrogen-receptor positive breast cancer risk in the French E3N cohort

Table 2 Associations between dietary exposure profiles to metalloestrogens (PC 1 to PC 4) obtained by principal component analysis and ERP breast cancer risk. Hazard Ratios (HR) and their 95% confidence intervals (95% CI) are estimated by Cox models (N = 66 722)

SD: Standard Deviation
Model 1: Adjusted for age (as the timescale) only
Model 2: Adjusted for age (as the timescale), birth generation (≤ 1930, (1930–1935], (1935–1940], (1940–1945, > 1945]), level of education (< 12 years, 12 to 14 years, > 14 years), current or past user of contraception (no, yes), BMI (missing data, < 18.5, (18.5–22.5], (22.5–25], (25–30], > 30 kg/m²)parity and age at first full-term pregnancy (FFTP) (nulliparous, 1 or 2 children and age at FFTP > 30 years, more than 2 children and age at FFTP < 30 years, age at FFTP ≥ 30 years), menopausal status and recent use of hormone replacement therapy (HRT) (pre-menopausal, post-menopausal with recent use of HRT, post-menopausal without recent use of HRT, post-menopausal with missing data on recent use of HRT), cumulative duration of breastfeeding (no breastfeeding, cumulative duration of breastfeeding < 6 months, duration of breastfeeding ≥ 6 months)
Model 3: Adjusted for Model 2 + smoking status (smoker, former smoker, never smoker), physical activity (in METs-hours/week, using linear terms), energy intake excluding fat and alcohol (in kcal/day, using linear terms), alcohol consumption (in g/day, modelled with penalized splines), fat consumption (in g/day, modelled with penalized splines) and adherence to the French dietary recommendation (using linear terms)

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