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Table 4 Odds ratios (ORs) and 95% confidence intervals (CIs) for hormone receptor-defined breast cancer by plasma concentrations of perfluoroalkyl substances

From: Plasma perfluoroalkyl substances and breast cancer risk in Brazilian women: a case–control study

PFASa

Range

 

Adjusted OR (95% CI)b

  

[ng/mL]

 

Joint ER/PR status

  

ER + and PR+

(139 cases, 443 controls)

 

ER + and PR–

(58 cases, 443 controls)

 

ER– and PR–

(94 cases, 443 controls)

Total PFHxS

       
 

< 80%ile

< 0.83

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

≥ 80%ile

0.83–5.74

 

0.48 (0.25, 0.93)

 

0.86 (0.37, 2.02)

 

0.51 (0.22, 1.20)

 

P

  

0.028

 

0.73

 

0.12

Total PFOS

       
 

Tertile 1

< 7.34

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Tertile 2

7.34–11.08

 

0.97 (0.55, 1.69)

 

0.84 (0.40, 1.75)

 

0.88 (0.47, 1.64)

 

Tertile 3

11.11–90.57

 

1.31 (0.67, 2.55)

 

0.63 (0.25, 1.59)

 

0.70 (0.32, 1.53)

 

P for trend

  

0.39

 

0.33

 

0.37

Total PFOA

       
 

Tertile 1

< 1.34

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Tertile 2

1.34–1.91

 

0.74 (0.42, 1.29)

 

0.94 (0.43, 2.03)

 

0.70 (0.37, 1.33)

 

Tertile 3

1.92–73.04

 

1.00 (0.55, 1.80)

 

1.24 (0.53, 2.86)

 

0.94 (0.47, 1.88)

 

P for trend

  

0.81

 

0.56

 

0.98

n-PFHpS

       
 

< Median

< 0.08

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Quartile 3

0.08–0.18

 

1.29 (0.74, 2.24)

 

1.18 (0.57, 2.45)

 

1.11 (0.60, 2.05)

 

Quartile 4

0.19–1.65

 

2.55 (1.41, 4.59)

 

1.87 (0.81, 4.30)

 

1.46 (0.71, 3.00)

 

P for trend

  

0.002

 

0.15

 

0.31

n-PFOS

       
 

Tertile 1

< 4.13

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Tertile 2

4.13–6.48

 

0.97 (0.56, 1.68)

 

0.92 (0.44, 1.92)

 

0.85 (0.47, 1.55)

 

Tertile 3

6.50–60.75

 

1.42 (0.74, 2.71)

 

0.79 (0.32, 1.93)

 

0.60 (0.28, 1.31)

 

P for trend

  

0.24

 

0.60

 

0.20

3 m-PFOS

       
 

< Median

< 0.39

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Quartile 3

0.39–0.55

 

1.12 (0.64, 1.96)

 

1.74 (0.82, 3.70)

 

1.83 (0.96, 3.50)

 

Quartile 4

0.56–11.77

 

1.17 (0.58, 2.36)

 

1.92 (0.70, 5.28)

 

1.94 (0.86, 4.41)

 

P for trend

  

0.67

 

0.20

 

0.11

4 m-PFOS

       
 

< Median

< 0.65

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Quartile 3

0.65–0.91

 

0.92 (0.51, 1.66)

 

0.97 (0.42, 2.22)

 

1.21 (0.63, 2.33)

 

Quartile 4

0.92–15.30

 

1.37 (0.69, 2.75)

 

1.94 (0.73, 5.17)

 

1.25 (0.53, 2.91)

 

P for trend

  

0.37

 

0.19

 

0.58

5 m-PFOS

       
 

Tertile 1

< 0.80

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Tertile 2

0.80–1.27

 

1.38 (0.77, 2.45)

 

0.91 (0.41, 2.01)

 

1.00 (0.53, 1.88)

 

Tertile 3

1.28–25.85

 

1.22 (0.62, 2.40)

 

0.99 (0.40, 2.47)

 

0.81 (0.37, 1.75)

 

P for trend

  

0.70

 

0.99

 

0.55

6 m-PFOS

       
 

Tertile 1

< 0.93

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Tertile 2

0.93–1.46

 

1.43 (0.81, 2.55)

 

0.78 (0.36, 1.69)

 

1.16 (0.63, 2.13)

 

Tertile 3

1.47–18.75

 

1.85 (0.97, 3.51)

 

1.09 (0.47, 2.55)

 

0.83 (0.40, 1.73)

 

P for trend

  

0.070

 

0.73

 

0.53

3,5 dm-PFOS

       
 

< Median

< 0.06

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Quartile 3

0.06–0.12

 

1.05 (0.63, 1.74)

 

1.21 (0.60, 2.43)

 

1.23 (0.69, 2.20)

 

Quartile 4

0.13–5.78

 

0.95 (0.54, 1.67)

 

1.16 (0.52, 2.58)

 

0.97 (0.49, 1.92)

 

P for trend

  

0.84

 

0.72

 

0.95

n-PFOA + 4 m-PFOA

      
 

Tertile 1

< 1.00

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Tertile 2

1.00–1.54

 

0.72 (0.41, 1.27)

 

0.79 (0.36, 1.73)

 

0.68 (0.36, 1.29)

 

Tertile 3

1.55–72.80

 

1.04 (0.58, 1.88)

 

1.13 (0.49, 2.61)

 

0.80 (0.40, 1.60)

 

P for trend

  

0.67

 

0.64

 

0.63

n-PFNA

       
 

< Median

< 0.19

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Quartile 3

0.19–0.27

 

1.36 (0.80, 2.33)

 

0.73 (0.34, 1.57)

 

0.76 (0.39, 1.50)

 

Quartile 4

0.28–3.89

 

1.01 (0.54, 1.90)

 

0.41 (0.17, 1.02)

 

0.70 (0.33, 1.52)

 

P for trend

  

0.88

 

0.053

 

0.33

n-PFDA

       
 

< Median

< 0.09

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Quartile 3

0.09–0.13

 

0.93 (0.55, 1.59)

 

1.88 (0.94, 3.79)

 

1.09 (0.59, 2.04)

 

Quartile 4

0.14–2.26

 

0.78 (0.39, 1.54)

 

0.62 (0.22, 1.71)

 

0.91 (0.41, 2.06)

 

P for trend

  

0.47

 

0.63

 

0.88

n-PFDoDA

       
 

< Median

< 0.05

 

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

Quartile 3

0.05–0.07

 

1.29 (0.74, 2.22)

 

1.01 (0.46, 2.21)

 

1.26 (0.65, 2.43)

 

Quartile 4

0.08–3.03

 

1.12 (0.64, 1.93)

 

1.23 (0.58, 2.63)

 

1.70 (0.91, 3.18)

 

P for trend

  

0.69

 

0.58

 

0.10

  1. For total PFHxS, women were dichotomized by 80%iles because of low detection frequency
  2. a Medians, tertiles, quartiles and 80%iles are based on the distribution of plasma PFAS concentrations among controls
  3. b The adjustment variables used in this analysis are essentially the same as in Model 2 in Table 2. However, we additionally adjusted for age (continuous) and ethnicity (Caucasian, mixed, Black, Japanese Brazilian)
  4. Bold font indicates a statistically significant association
  5. ER-/PR + breast cancer were not analyzed because of the small number of cases
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Environmental Health

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