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Table 3 Differences in birth outcomes stratified on offspring sex and 95% confidence intervals in adjusted linear regression models according to quartiles of osmolality adjusted bisphenol A (BPA) concentrations in urine from 832 pregnant women

From: Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort

BPA (ng/ml(osm))

Birth weight (g)

 

Birth length (cm)

 

Head circumference (cm)

 

Abdominal circumference (cm)

n

β, 95% CI

p-value

 

n

β, 95% CI

p-value

 

n

β, 95% CI

p-value

 

n

β, 95% CI

p-value

Male offspring

BPA quartile

               

 Q1: LOD to < 0.56

111

Reference

  

110

Reference

  

111

Reference

  

111

Reference

 

 Q2: 0.56 to < 1.39

111

-57 (-167; 54)

0.31

 

109

-0.44 (-0.93; 0.06)

0.08

 

110

0.30 (-0.59; 1.19)

0.46

 

110

-0.29 (-1.42; 0.84)

0.61

 Q3: 1.39 to < 2.40

111

-42 (-153; 68)

0.45

 

111

-0.20 (-0.69; 0.29)

0.43

 

111

0.56 (-0.32; 1.44)

0.21

 

111

-0.01 (-1.14; 1.11)

0.98

 Q4: ≥ 2.40

111

-115 (-225; -4)

0.04

 

110

-0.49 (-0.98; 0.004)

0.05

 

110

0.82 (-0.07; 1.70)

0.07

 

110

0.23 (-0.90; 1.36)

0.69

P-trenda

  

0.06

   

0.12

   

0.06

   

0.60

Female offspring

BPA quartile

               

 Q1: LOD to < 0.53

97

Reference

  

97

Reference

  

97

Reference

  

97

Reference

 

 Q2: 0.53 to < 1.28

97

-94 (-204; 16)

0.09

 

96

0.02 (-0.46; 0.49)

0.95

 

96

-0.43 (-1.11; 0.24)

0.21

 

96

-0.93 (-1.82; -0.03)

0.04

 Q3: 1.28 to < 2.44

97

-49 (-158; 59)

0.37

 

97

0.02 (-0.44; 0.49)

0.93

 

97

-0.04 (-0.70; 0.62)

0.90

 

97

-0.03 (-0.91; 0.85)

0.95

 Q4: ≥ 2.44

97

-69 (-178; 40)

0.22

 

97

-0.08 (-0.55; 0.38)

0.72

 

97

0.05 (-0.61; 0.72)

0.88

 

97

-0.43 (-1.31; 0.46)

0.34

P-trenda

  

0.35

   

0.74

   

0.62

   

0.74

Maternal BPA x Offspring sex

             

P-trenda

832

 

0.18

 

827

 

0.33

 

829

 

0.65

 

829

 

0.42

  1. Abbreviations: CI, confidence interval; LOD, limit of detection; BPA, bisphenol A
  2. All estimates adjusted for maternal age, maternal pre-pregnancy BMI, maternal smoking during pregnancy, maternal educational status, gestational age at birth and parity
  3. ap-trend across quartiles of BPA concentration
  4. bp-values for the interaction term, testing the null hypothesis that the estimates for males and females are equal
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Environmental Health

ISSN: 1476-069X