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Table 5 Maternal PFAS concentrations at Visit 1 presented as mean ± standard deviation. Percentage change in plasma lipid concentration at Visit 1 for a doubling of serum PFAS concentration presented as relative change with 95% confidence intervals. Associations were estimated in a linear mixed model and adjusted for pre-pregnancy BMI, maternal age, parity, and daily minutes of moderate-to-vigorous-intensity physical actitivty

From: Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women—temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations

 

TC

HDL-C

TC/HDL-C

LDL-C

Triglyceride

Visit 1 (mmol/L)

4.52 ± 0.79

1.74 ± 0.35

2.68 ± 0.61

2.17 ± 0.64

1.33 ± 0.61

 

Change [95% CI]

Change [95% CI]

Change [95% CI]

Change [95% CI]

Change [95% CI]

PFOS

−0.49 [−4.64;3.84]

5.83 [1.23;10.63]*

−5.95 [−10.35;1.35]*

−3.62 [−10.46;3.73]

−6.12 [−15.45;4.25]

PFOA

−0.82 [−4.44;2.95]

5.64 [1.63;9.80]*

−6.10 [−9.93;2.10]*

−5.92 [−11.75;0.29]

−1.93 [−10.55;7.51]

PFHxS

−0.67 [−3.60;2.34]

5.16 [1.97;8.45]*

−5.53 [−8.62;−2.34]*

−4.51 [−9.29;0.52]

−5.00 [−11.72;2.24]

PFNA

0.22 [−4.05;4.67]

8.01 [3.29;12.95]*

−7.20 [−11.60;−2.58]*

−6.30 [−13.05;0.97]

0.22 [−9.98;11.57]

PDFA

−0.40 [−4.58;3.96]

6.13 [1.50;10.98]*

−6.13 [−10.54;−1.49]*

−4.84 [−11.61;2.46]

−4.77 [−14.31;5.83]

PFUnDA

0.63 [−2.94;4.34]

7.06 [3.16;11.10]*

−5.98 [−9.70;−2.10]*

−3.16 [−9.02;3.08]

−3.60 [−11.82;5.38]

  1. Visit 1: Gestational age week 6 + 1 to 15 + 0
  2. PFAS per- and polyfluoroalkyl substances, PFOS perfluorooctane sulfonic acid, PFOA perfluorooctanoic acid, PFHxS perfluorohexane sulfonate, PFNA; perfluorononanoic acid, PFDA; perfluorodecanoic acid, PFUnDA; perfluoroundecanoic acid, TC Total cholesterol, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol
  3. *p-value < 0.05